The Duke of York gives up his title as the Duke.
The royal is surrendering his designations, among them the York's Duke, he has announced in a own words.
He has been under mounting attention over his associations with sex offender the financier, with demands for the Palace to take action against him.
That now appears to have led to the royal deciding to voluntarily return his titles and to relinquish membership of the Order of the Garter.
In his statement he said he continued to "strongly dispute the accusations against me".
"In consultation with the King, and my immediate and extended family, we have decided the ongoing claims about me divert from the responsibilities of the monarch and the monarchy," said a message from Prince Andrew.
"I have decided, as I always have, to put my obligation to my family and country first.
"I uphold my resolution five years ago to withdraw from royal engagements.
"With His Majesty's approval, we feel I must now go a step further. I will therefore no longer employ my honor or the honours which have been bestowed on me. As I have said earlier, I strongly deny the claims against me."
The royal has encountered a series of scandals, including a lawsuit he ended with Virginia Giuffre, doubts about his economic affairs and his association with an accused Chinese spy.
He will remain a member of royalty - but will discontinue to be the Duke of York, a honor bestowed from his parent, the former monarch.
The prince had already ended to be a "active member" and had lost the use of his HRH title and no longer was seen at public engagements. His position now will be even more diminished.
His previous partner will be known as Ferguson and no longer the Duchess, but their offspring will carry on to have the title of princesses.
He has been under intense examination over his associations with disgraced financier Jeffrey Epstein, more lately including questions about when he had actually cut off communication.
In his BBC Newsnight interview, he had said that he had severed all links with Jeffrey Epstein after they had been seen together in NYC in late 2010.
But correspondence sent in early 2011 later came to light suggesting that the prince had in private remained in contact with Epstein, such as sending a communication: "Stay in contact and we'll meet again soon!"
There had been increasing annoyance in Buckingham Palace at the controversies that persisted to surround the royal.
Next week a book released after death by Giuffre will be published which is expected to bring more scrutiny on the royal's involvement with the plaintiff and Epstein.